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A GB200 NVL72 puts 72 GPUs in one NVLink domain. What does that change for MoE serving and for prefill-decode disaggregation?

Eight GPUs per NVLink domain shaped every serving layout of the Hopper era. Seventy-two moves the boundary that expert parallelism and KV transfer used to cross over the NIC. The answer prices what moves inside the rack, what still does not fit, and the failure mode that comes with it.

Updated Oct 2026 · Worked answers on inference mechanisms, with calculations, implementation details, and follow-up questions.

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